(Science) – A simple change in electric charge may make the difference between someone getting the medicine they need and a trip to the emergency room—at least if a new study bears out. Researchers investigating the toxicity of particles designed to ferry drugs inside the body have found that carriers with a positive charge on their surface appear to cause damage if they reach the brain.
(Scientific American) – Modern cancer care has the potential to generate huge amounts of data. When a patient is diagnosed, the tumour’s genome might be sequenced to see if it is likely to respond to a particular drug. The sequencing might be repeated as treatment progresses to detect changes. The patient might have his or her normal tissue sequenced as well, a practice that is likely to grow as costs come down.
(World Health Organization) – Failure to provide adequate HIV services for key groups – men who have sex with men, people in prison, people who inject drugs, sex workers and transgender people – threatens global progress on the HIV response, warns WHO. These people are most at risk of HIV infection yet are least likely to have access to HIV prevention, testing and treatment services. In many countries they are left out of national HIV plans, and discriminatory laws and policies are major barriers to access.
(Reuters) – Combining two types of polio vaccine, including one that is injected rather than given orally, appears to give better immunity and could speed efforts to eradicate the crippling disease, scientists said on Friday. British and Indian researchers said the inactivated polio vaccine (IPV), which is given by injection, could provide better and longer lasting protection if given alongside the more commonly used live oral polio vaccine (OPV).
(Los Angeles Times) – Antibiotic use has surged by 36% worldwide in a decade, much of it unwarranted, according to a new study. The rise, particularly in countries with a burgeoning middle class, heightens concerns that overuse of antibiotics is leaving more of the world’s population vulnerable to drug-resistant bacteria, according to the authors of the analysis, published online Thursday in the journal Lancet Infectious Diseases. The study provides the most comprehensive long-term view of antibiotic use in 71 countries from 2000 to 2010.
(UPI) – As employment numbers for the rest of the country have slowly improved in recent years, more and more adults with serious mental illness find themselves unable to find or keep a job. According to a new study published by the National Alliance on Mental Illness, more than 80 percent of adults suffering from serious mental illness are unemployed.
(San Francisco Gate) – Two days after the ex-president of California’s stem cell agency became a board director at a company that is receiving funding from the agency, the agency said Wednesday it is taking steps to “mitigate a potential conflict of interest.” Earlier this week, StemCells Inc. in Newark said that Dr. Alan Trounson would join its board of directors and receive cash and stock in the company. Trounson stepped down this spring from leading the California Institute for Regenerative Medicine, which is distributing $3 billion in taxpayer money to stem cell research projects around the state with the intent of developing therapies for debilitating conditions.
(CBS Boston) – Neeburbunn Lewis has a beautiful little girl thanks to IVF. But the fertility medications also caused serious complications that landed her in the hospital. When she and her husband wanted a second child she had second thoughts about trying IVF again. “Traditional IVF wasn’t an option for me, personally, because I did not want to risk going through overstimulation again.”
(Phys.org) – Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene for embryonic stem cells, also regulates cell division in stratified epithelia—those that form part of the epidermis of the skin or cover the oesophagus or the vagina—in adult organisms. According to the conclusions of the study, published in the journal Nature Communications, this factor could also play a role in the formation of tumours derived from stratified epithelia of the oesophagus and skin.
(Medical Xpress) – Columbia University Medical Center (CUMC) researchers have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss. The approach, the first of its kind, takes advantage of induced pluripotent stem (iPS) cell technology to transform skin cells into retinal cells, which are then used as a patient-specific model for disease study and preclinical testing.